The museum offers a journey into the past of the Madrid Region, from its first inhabitants to the 18th century.
The collection tells us about the history of Madrid with material evidence of its past. It covers the evolution of the landscape and wildlife until the first settlers arrived, the life of these settlers, the first producing societies, the Roman occupation, the Middle Ages, and the transfer of the Spanish Court from Valladolid to Madrid. It also has a section on archaeology as a science and on its presence in the Madrid Region. The museum is situated in the historic centre of Alcalá de Henares, which has the UNESCO World Heritage designation, and it is housed in the Dominican Convent of La Madre de Dios, one of the largest convents in the city. The history of this building is also explained in the museum.