Located in the former Santa Cruz Hospital.

The outstanding features of this 16th-century building are its Plateresque façade and its courtyard and staircase, the work of Covarrubias, and its Mudéjar and Renaissance coffered ceilings. The museum's collection is divided into three sections: Archaeology, devoted to the Roman, Visigothic, Moorish and Mudéjar cultures; Fine Arts, with an excellent selection of 16th- and 17th-century paintings from Toledo, and works by such artists as El Greco; and Industrial Arts, with examples of popular culture and traditional local crafts (ceramics, glass, fabrics, wrought iron and precious metalwork).