This was the biggest industrial building in Europe in the 18th century.

There are paintings inside the Tobacco Factory recalling the women cigar makers who worked there. Outstanding among these is the painting by Gonzalo Bilbao, whose most well known depictions of customs and manners are in the Seville Museum of Fine Arts, including other portrayals of women cigar makers. A ditch was dug around the factory with several sentry boxes, indicating a defensive use. Today it is the headquarters of Seville University.